Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …

During recent years, considerable progress has been made in understanding the
etiopathogenesis of periodontitis in its various forms and their interactions with the host …

Simple Summary Cancer cells rely on the surrounding environment to grow and spread.
This environment contains structural components, secreted factors, immune cells, and other …

Transforming growth factor-β (TGF-β) signaling is essential in embryo development and
maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on …

Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism
and cope with microenvironmental perturbations. Moreover, autophagy connects cellular …

Cancer‐associated fibroblasts (CAFs) as a predominant cell component in the tumour
microenvironment (TME) play an essential role in tumour progression. Our earlier studies …

Although best understood as a degradative pathway, recent evidence demonstrates
pronounced involvement of the macroautophagic/autophagic molecular machinery in …

Abstract Cancer-associated fibroblasts (CAFs), the main stromal component of the tumor
microenvironment (TME), play multifaceted roles in cancer progression through paracrine …