Reviewing the potential of probiotics, prebiotics and synbiotics: advancements in treatment of ulcerative colitis

A Jadhav, S Jagtap, S Vyavahare… - Frontiers in Cellular …, 2023 - frontiersin.org
Inflammatory bowel diseases (IBD) like Crohn's and ulcerative colitis (UC) are multifactorial
pathologies caused by environmental factors and genetic background. UC is a chronic …

Low-dose azathioprine in combination with allopurinol: the past, present and future of this useful duo

AK Turbayne, MP Sparrow - Digestive Diseases and Sciences, 2022 - Springer
The inflammatory bowel diseases (IBD) are complex immune-mediated inflammatory
diseases that are associated with significant morbidity around the world. As our …

Tofacitinib in acute severe ulcerative colitis (TACOS): A randomized controlled trial: Tofacitinib in ASUC

A Singh, MK Goyal, V Midha, R Mahajan… - Official journal of the …, 2022 - journals.lww.com
Background: Intravenous corticosteroids are the mainstay of treatment of patients
hospitalized with acute severe ulcerative colitis (ASUC). However, 30%-40% of the patients …

Tofacitinib versus oral prednisolone for induction of remission in moderately active ulcerative colitis [ORCHID]: a prospective, open-label, randomized, pilot study

A Singh, V Midha, K Kaur, R Mahajan… - Journal of Crohn's …, 2024 - academic.oup.com
Background Oral corticosteroids are first-line agents to induce remission in moderately
active ulcerative colitis [UC], but are associated with adverse effects. We compared the …

Uphill battle: Innovation of thiopurine therapy in global inflammatory bowel disease care

AB Bayoumy, CJJ Mulder, AR Ansari… - Indian journal of …, 2024 - Springer
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract that encompasses two major conditions: Crohn's disease (CD) and ulcerative colitis …

Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α

J Park, JH Cheon - The Korean journal of internal medicine, 2022 - pmc.ncbi.nlm.nih.gov
The incidence and prevalence of inflammatory bowel diseases (IBDs) are rapidly increasing
worldwide. IBDs are considered an emerging problem not only in Western countries but also …

Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion

Y Fukumoto, R Kyono, Y Shibukawa, Y Tanaka… - Journal of Biological …, 2024 - jbc.org
It is known that the recommended dietary allowance of selenium (Se) is dangerously close
to its tolerable upper intake level. Se is detoxified and excreted in urine as …

Ulcerative colitis: molecular insights and intervention therapy

Y Liang, Y Li, C Lee, Z Yu, C Chen, C Liang - Molecular biomedicine, 2024 - Springer
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by abdominal
pain, diarrhea, rectal bleeding, and weight loss. The pathogenesis and treatment of UC …

Long‐term safety and effectiveness of azathioprine in the management of inflammatory bowel disease: A real‐world experience

RV Yewale, BS Ramakrishna, BV Doraisamy… - JGH …, 2023 - Wiley Online Library
Abstract Background and Aim Azathioprine (AZA) forms the cornerstone for maintenance of
sustained remission in inflammatory bowel disease (IBD). There is apprehension regarding …

Ulcerative colitis in adulthood and in older patients: same disease, same outcome, same risks?

W Fries, MG Demarzo, G Navarra, A Viola - Drugs & Aging, 2022 - Springer
The number of patients with inflammatory bowel disease (IBD) approaching an older age,
together with the number of over-60-year-old patients newly diagnosed with IBD, is steadily …