Mitochondria in health, disease, and aging

JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Pulmonary hypertension

A Mocumbi, M Humbert, A Saxena, ZC **g… - Nature reviews Disease …, 2024 - nature.com
Pulmonary hypertension encompasses a range of conditions directly or indirectly leading to
elevated pressures within the pulmonary arteries. Five main groups of pulmonary …

Mitophagy, mitochondrial homeostasis, and cell fate

K Ma, G Chen, W Li, O Kepp, Y Zhu… - Frontiers in cell and …, 2020 - frontiersin.org
Mitochondria are highly plastic and dynamic organelles that have graded responses to the
changing cellular, environmental, and developmental cues. Mitochondria undergo constant …

[HTML][HTML] Metabolism of vascular smooth muscle cells in vascular diseases

J Shi, Y Yang, A Cheng, G Xu… - American Journal of …, 2020 - journals.physiology.org
Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer
of arteries and are essential for arterial physiology and pathology. It is becoming …

Pulmonary arterial hypertension: pathogenesis and clinical management

T Thenappan, ML Ormiston, JJ Ryan, SL Archer - Bmj, 2018 - bmj.com
Pulmonary hypertension is defined as a resting mean pulmonary artery pressure of 25 mm
Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of …

Drp1-dependent mitochondrial fission in cardiovascular disease

J **, X Wei, X Zhi, X Wang, D Meng - Acta Pharmacologica Sinica, 2021 - nature.com
Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to
modulate their morphology, distribution, and function, which are referred as 'mitochondrial …

Mitochondrial dynamics controls T cell fate through metabolic programming

MD Buck, D O'Sullivan, RIK Geltink, JD Curtis… - Cell, 2016 - cell.com
Summary Activated effector T (TE) cells augment anabolic pathways of metabolism, such as
aerobic glycolysis, while memory T (TM) cells engage catabolic pathways, like fatty acid …

[HTML][HTML] Metabolic reprogramming, oxidative stress, and pulmonary hypertension

MD Pokharel, DP Marciano, P Fu, MC Franco… - Redox biology, 2023 - Elsevier
Mitochondria are highly dynamic organelles essential for cell metabolism, growth, and
function. It is becoming increasingly clear that endothelial cell dysfunction significantly …

N4‐Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF‐1α Positive Feedback Loop

Q Yang, X Lei, J He, Y Peng, Y Zhang, R Ling… - Advanced …, 2023 - Wiley Online Library
Anti‐angiogenic therapy has long been considered a promising strategy for solid cancers.
Intrinsic resistance to hypoxia is a major cause for the failure of anti‐angiogenic therapy, but …

Mitochondrial dynamics, mitophagy and cardiovascular disease

C Vásquez‐Trincado, I García‐Carvajal… - The Journal of …, 2016 - Wiley Online Library
Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …