Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization

Y Wu, K Chen, J Wang, M Chen, W Dai… - Journal of the American …, 2024 - ACS Publications
Polypeptides have the same or similar backbone structures as proteins and peptides,
rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides …

Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications

C Englert, JC Brendel, TC Majdanski, T Yildirim… - Progress in Polymer …, 2018 - Elsevier
The administration of drugs, as a main challenge of pharmaceutical and medicinal
applications, has certainly benefited from the application of synthetic polymers. However …

Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications

A Birke, J Ling, M Barz - Progress in Polymer Science, 2018 - Elsevier
Although the first polysarcosine (pSar) synthesis by Wesseley et al. was reported almost a
century ago, it was only recently that pSar gained broader attention and is considered a …

Functional polypeptide and hybrid materials: Precision synthesis via α-amino acid N-carboxyanhydride polymerization and emerging biomedical applications

C Deng, J Wu, R Cheng, F Meng, HA Klok… - Progress in Polymer …, 2014 - Elsevier
Polypeptides derived from naturally occurring α-amino acids have emerged as a unique and
versatile family of bio-inspired biomaterials that can be tailor-made for varying biomedical …

Peptoids and polypeptoids at the frontier of supra-and macromolecular engineering

N Gangloff, J Ulbricht, T Lorson, H Schlaad… - Chemical …, 2016 - ACS Publications
In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides

Y Wu, D Zhang, P Ma, R Zhou, L Hua, R Liu - Nature communications, 2018 - nature.com
Polypeptides have broad applications and can be prepared via ring-opening polymerization
of α-amino acid N-carboxyanhydrides (NCAs). Conventional initiators, such as primary …

Synthetic polypeptides for biomedical applications

TJ Deming - Progress in Polymer Science, 2007 - Elsevier
This article summarizes recent developments in the synthesis of copolypeptides from
polymerization of α-amino acid-N-carboxyanhydrides (NCAs), focusing on their …

Hydrogels as smart biomaterials

J Kopeček, J Yang - Polymer international, 2007 - Wiley Online Library
Hydrogels were the first biomaterials rationally designed for human use. Beginning with the
pioneering work of Wichterle and Lím on three‐dimensional polymers that swell in water, we …

Stimuli‐sensitive synthetic polypeptide‐based materials for drug and gene delivery

C He, X Zhuang, Z Tang, H Tian… - Advanced healthcare …, 2012 - Wiley Online Library
Stimuli‐sensitive synthetic polypeptides are unique biodegradable and biocompatible
synthetic polymers with structures mimicking natural proteins. These polymers exhibit …