Adenosine compartmentalization has a profound impact on immune cell function by
regulating adenosine localization and, therefore, extracellular signaling capabilities, which …

In the last 15 years, several research efforts have been directed towards the representation
and the analysis of metabolic pathways by using Petri nets. The goal of this paper is twofold …

Abstract Systems Biology has taken advantage of computational tools and high-throughput
experimental data to model several biological processes. These include signaling, gene …

Graph theory has been a valuable mathematical modeling tool to gain insights into the
topological organization of biochemical networks. There are two types of insights that may …

More and more computational techniques have been applied to model biological systems,
especially signaling pathways in medical systems. Due to the large number of experimental …

Cell Illustrator is a software platform for Systems Biology that uses the concept of Petri net for
modeling and simulating biopathways. It is intended for biological scientists working at …

Background Cellular response to external stimuli requires propagation of corresponding
signals through molecular signaling pathways. However, signaling pathways are not …

Motivation: Prediction of synergistic effects of drug combinations has traditionally been relied
on phenotypic response data. However, such methods cannot be used to identify molecular …

In biological systems, pathways define complex interaction networks where multiple
molecular elements are involved in a series of controlled reactions producing responses to …

Biochemical networks depict the chemical interactions that take place among elements of
living cells. They aim to elucidate how cellular behavior and functional properties of the cell …