Intron retention (IR) occurs when a complete and unspliced intron remains in mature mRNA.
An increasing body of literature has demonstrated a major role for IR in numerous biological …

Cellular activation is mainly defined as the response of a cell to exogenous signals
eventually leading to changes in protein expression and cellular function. Originally …

M2 polarization of macrophages is essential for their function in immunologic tolerance,
which might promote tumorigenesis. However, the molecular mechanism behind the …

African swine fever virus (ASFV) has a major global economic impact. With a case fatality in
domestic pigs approaching 100%, it currently presents the largest threat to animal farming …

Mycobacterium tuberculosis (Mtb) is responsible for approximately 1.5 million deaths each
year. Though 10% of patients develop tuberculosis (TB) after infection, 90% of these …

Mycobacterium tuberculosis (Mtb) infection reveals complex and dynamic host-pathogen
interactions, leading to host protection or pathogenesis. Using a unique transcriptome …

Macrophages polarize into functionally distinct subtypes while responding to
microenvironmental cues. The identity of proximal transcription factors (TFs) downstream …

Background A growing body of research has shown that the phenotypic change in
macrophages from M0 to M1 is essential for the start of the inflammatory process in septic …

Obesity is a major public health burden worldwide and is characterized by chronic low-
grade inflammation driven by the cooperation of the innate immune system and …

Macrophages are the mature form of monocytes that have high plasticity and can shift from
one phenotype to another by the process of macrophage polarization. Macrophage has …