The schizophrenia brain is differentiated from the normal brain by subtle changes, with
significant overlap in measures between normal and disease states. For the past 25 years …

The accurate function of the central nervous system (CNS) depends of the consonance of
multiple genetic programs and external signals during the ontogenesis. A variety of …

Since the late 1970s glycine has been considered an important inhibitory neurotransmitter in
brain stem and medulla. The description of its involvement in the mechanism of action of the …

Glycine receptors (GlyR) are inhibitory Cys-loop ion channels that contribute to the control of
excitability along the central nervous system (CNS). GlyR are found in the spinal cord and …

Recreational use of alcohol is a social norm in many communities worldwide. Alcohol use in
moderation brings pleasure and may protect the cardiovascular system. However, excessive …

Emerging evidence supports the therapeutic potential of cannabinoids in Alzheimer's
disease (AD), but the underlying mechanism upon how cannabinoids impact brain cognition …

In recent years there has been an increase in the understanding of ethanol actions on the
type A γ-aminobutyric acid chloride channel (GABAAR), a member of the pentameric ligand …

Identification of ethanol's (EtOH) primary molecular brain targets and determination of their
functional role is an ongoing, important quest. Pentameric ligand‐gated ion channels, that is …

Although glycine receptor Cl-channels (GlyRs) have long been known to mediate inhibitory
neurotransmission onto spinal nociceptive neurons, their therapeutic potential for peripheral …

Glycine receptors are ligand-gated ion channels that mediate synaptic inhibition throughout
the mammalian spinal cord, brainstem, and higher brain regions. They have recently …