As an important characteristic of tumor, acidic tumor microenvironment (TME) is closely
related to immune escape, invasion, migration and drug resistance of tumor. The acidity of …

In recent years, the abnormal glucose metabolism of tumor cells has attracted increasing
attention. Abnormal glucose metabolism is closely related to the occurrence and …

Abstract Monocarboxylate transporter-1 (MCT-1) inhibitors were screened from the Fv-
antibody library, which contained complementary determining region 3 with randomized …

Abstract CircZBTB44 (hsa_circ_0002484) has been identified to be upregulated in renal cell
carcinoma (RCC) tissues, while its role and contribution in RCC remain elusive. We …

Lenvatinib is a multikinase inhibitor that suppresses vascular endothelial growth factor
receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor …

Cancer is one of the leading causes of death worldwide, resulting in the deaths of millions of
individuals. Owing to the development of drug resistance to conventional therapies …

Medicinal polypharmacology is one answer to the complex reality of multifactorial human
diseases that are often unresponsive to single-targeted treatment. It is an admittance that …

Simple Summary Reusing drugs could potentially shorten the development time for the
effective treatment of dementia. Here, we tested a drug—dimethyl fumarate—for its efficacy …

Indole and quinoline structures are present in numerous biologically active molecules,
making the synthesis of their glycosylation products a subject of extensive research and …

In this study, with the aim of identifying new anticancer agents, we synthesized a series of
tryptanthrin derivatives. All the synthesized compounds were investigated for their …