Central nervous system regulation of organismal energy and glucose homeostasis

MG Myers Jr, AH Affinati, N Richardson… - Nature …, 2021 - nature.com
Growing evidence implicates the brain in the regulation of both immediate fuel availability
(for example, circulating glucose) and long-term energy stores (that is, adipose tissue mass) …

New findings on brain actions of growth hormone and potential clinical implications

J Donato Jr, JJ Kopchick - Reviews in Endocrine and Metabolic Disorders, 2024 - Springer
Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The
classical effects of GH comprise the stimulation of cell proliferation, tissue and body growth …

Central regulation of metabolism by growth hormone

J Donato Jr, F Wasinski, IC Furigo, M Metzger… - Cells, 2021 - mdpi.com
Growth hormone (GH) is secreted by the pituitary gland, and in addition to its classical
functions of regulating height, protein synthesis, tissue growth, and cell proliferation, GH …

Growth hormone action in somatostatin neurons regulates anxiety and fear memory

WO Dos Santos, VAL Juliano, FM Chaves… - Journal of …, 2023 - Soc Neuroscience
Dysfunctions in growth hormone (GH) secretion increase the prevalence of anxiety and
other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been …

Understanding the role of growth hormone in situations of metabolic stress

MR Tavares, R Frazao, J Donato - Journal of Endocrinology, 2023 - joe.bioscientifica.com
Growth hormone (GH) is secreted by the anterior pituitary gland and plays a key role in
controlling tissue and body growth. While basal GH secretion is considerably reduced along …

Characterization and regulation of the neonatal growth hormone surge

DO Gusmao, LMM de Sousa, ME de Sousa… - …, 2024 - academic.oup.com
High neonatal growth hormone (GH) secretion has been described in several species.
However, the neuroendocrine mechanisms behind this surge remain unknown. Thus, the …

Maternal adaptations to food intake across pregnancy: Central and peripheral mechanisms

GS Clarke, KL Gatford, RL Young, DR Grattan… - …, 2021 - Wiley Online Library
A sufficient and balanced maternal diet is critical to meet the nutritional demands of the
develo** fetus and to facilitate deposition of fat reserves for lactation. Multiple adaptations …

[HTML][HTML] Effects of growth hormone in the central nervous system

F Wasinski, R Frazão, J Donato - Archives of endocrinology and …, 2020 - SciELO Brasil
Growth hormone (GH) is best known for its effect stimulating tissue and somatic growth
through the regulation of cell division, regeneration and proliferation. However, GH …

New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes

A Fosch, S Zagmutt, N Casals… - International Journal of …, 2021 - mdpi.com
Despite the substantial role played by the hypothalamus in the regulation of energy balance
and glucose homeostasis, the exact mechanisms and neuronal circuits underlying this …

Increased GH secretion and body growth in mice carrying ablation of IGF-1 receptor in GH-releasing hormone cells

DO Gusmao, ME de Sousa, MR Tavares… - …, 2022 - academic.oup.com
Growth hormone (GH) secretion is controlled by short and long negative feedback loops. In
this regard, both GH (short-loop feedback) and insulin-like growth factor 1 (IGF-1; long-loop …