The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and
extrinsic factors influence signaling along this axis, modulating the function of both the …

Irritable bowel syndrome (IBS) is the most prevalent disorder of brain-gut interactions that
affects between 5 and 10% of the general population worldwide. The current symptom …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …

Increasing evidence supports the notion that neuroinflammation plays a critical role in the
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …

The high comorbidity between obesity and mental disorders, such as depression and
anxiety, often exacerbates metabolic and neurological symptoms significantly. However …

Cannabidiol (CBD), the major nonpsychoactive Cannabis constituent, has been proposed
for the treatment of a wide panel of neurological and neuropsychiatric disorders, including …

Background: Depression or Major depressive disorder (MDD) is a prolonged condition of
sadness. MDD is the most common mental disorder that affects more than 264 million …

Quercetin is a naturally occurring bioactive flavonoid abundant in many plants and fruits.
Quercetin and its derivatives have shown an array of pharmacological activities in preclinical …

Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop receptor family are key
players in fast signal transduction throughout the nervous system. They have been shown to …