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Sex hormone signaling and regulation of immune function
Immune responses to antigens, including innocuous, self, tumor, microbial, and vaccine
antigens, differ between males and females. The quest to uncover the mechanisms for …
antigens, differ between males and females. The quest to uncover the mechanisms for …
Mechanisms driving gender differences in asthma
Abstract Purpose of Review Many phenotypes of asthma exist, ranging from mild asthma
with onset during childhood to severe asthma with later onset, making asthma a broad …
with onset during childhood to severe asthma with later onset, making asthma a broad …
Hormones, sex, and asthma
Objective To summarize the current literature on the sex disparity in asthma and the role of
sex hormone signaling in allergic and neutrophilic airway inflammation. Data Sources …
sex hormone signaling in allergic and neutrophilic airway inflammation. Data Sources …
Estrogen Receptor Downregulates Expression of PD-1/PD-L1 and Infiltration of CD8+ T Cells by Inhibiting IL-17 Signaling Transduction in Breast Cancer
C Shuai, X Yang, H Pan, W Han - Frontiers in oncology, 2020 - frontiersin.org
Background: The relationship between the interleukin 17 (IL-17) family of cytokines and
breast cancer has been widely studied in recent years. Many studies have revealed …
breast cancer has been widely studied in recent years. Many studies have revealed …
Cytokines, C-reactive protein, and risk of incident hypertension in the REGARDS study
BACKGROUND: Hypertension is a highly prevalent cardiovascular disease risk factor that
may be related to inflammation. Whether adverse levels of specific inflammatory cytokines …
may be related to inflammation. Whether adverse levels of specific inflammatory cytokines …
Tofacitinib restores the balance of γδTreg/γδT17 cells in rheumatoid arthritis by inhibiting the NLRP3 inflammasome
X Yang, N Zhan, Y **, H Ling, C **ao, Z **e… - …, 2021 - pmc.ncbi.nlm.nih.gov
Objective: Tofacitinib (TOF) is a Janus kinase (JAK) inhibitor used in the treatment of
rheumatoid arthritis (RA), but the mechanism of its action remains unclear. In this study, we …
rheumatoid arthritis (RA), but the mechanism of its action remains unclear. In this study, we …
[HTML][HTML] Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias
Neurological conditions such as Alzheimer's disease (AD) and related dementias (ADRD)
present with many challenges due to the heterogeneity of the related disease (s), making it …
present with many challenges due to the heterogeneity of the related disease (s), making it …
Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses
Pregnant women infected with pathogenic respiratory viruses, such as influenza A viruses
(IAV) and coronaviruses, are at higher risk for mortality, hospitalization, preterm birth, and …
(IAV) and coronaviruses, are at higher risk for mortality, hospitalization, preterm birth, and …
Th17 cells and IL‐17 as novel immune targets in ovarian cancer therapy
M Bilska, A Pawłowska, E Zakrzewska… - Journal of …, 2020 - Wiley Online Library
Ovarian cancer (OC) is usually diagnosed at an advanced stage and is related with poor
prognosis. Despite numerous studies, the pathogenesis of OC is still unknown. Recent …
prognosis. Despite numerous studies, the pathogenesis of OC is still unknown. Recent …
HMGB1-TLR4-IL23-IL17A axis promotes paraquat-induced acute lung injury by mediating neutrophil infiltration in mice
B Yan, F Chen, L Xu, J **ng, X Wang - Scientific reports, 2017 - nature.com
Paraquat is a poisoning herbicide that primarily targets lung, leading to severe acute lung
injury characterized by extensive neutrophil infiltration. However, the mechanisms …
injury characterized by extensive neutrophil infiltration. However, the mechanisms …