Why do many psychiatric disorders emerge during adolescence?
The peak age of onset for many psychiatric disorders is adolescence, a time of remarkable
physical and behavioural changes. The processes in the brain that underlie these …
physical and behavioural changes. The processes in the brain that underlie these …
Dendritic spine pathology in schizophrenia
Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …
impairments in perception, cognition and motivation. These impairments reflect alterations in …
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning
Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which
is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of …
is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of …
Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk
Background Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms
have been observed to show a steeper rate of cortical gray matter reduction compared with …
have been observed to show a steeper rate of cortical gray matter reduction compared with …
[HTML][HTML] Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care
The lifespan of people with severe mental illness (SMI) is shorter compared to the general
population. This excess mortality is mainly due to physical illness. We report prevalence …
population. This excess mortality is mainly due to physical illness. We report prevalence …
Association of structural magnetic resonance imaging measures with psychosis onset in individuals at clinical high risk for develo** psychosis: an ENIGMA working …
Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Progressive grey matter loss has been demonstrated among clinical high-risk (CHR)
individuals who convert to psychosis, but it is unknown whether these changes occur prior to …
individuals who convert to psychosis, but it is unknown whether these changes occur prior to …
[HTML][HTML] Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro imaging genetics through meta …
Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …
fully understood, despite hundreds of published structural brain imaging studies. This study …
Biomarkers and clinical staging in psychiatry
Personalized medicine is rapidly becoming a reality in today's physical medicine. However,
as yet this is largely an aspirational goal in psychiatry, despite significant advances in our …
as yet this is largely an aspirational goal in psychiatry, despite significant advances in our …
Sex/gender differences in the brain and cognition in schizophrenia
A Mendrek, A Mancini-Marïe - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
The early conceptualizations of schizophrenia have noted some sex/gender differences in
epidemiology and clinical expression of the disorder. Over the past few decades, the interest …
epidemiology and clinical expression of the disorder. Over the past few decades, the interest …