The peak age of onset for many psychiatric disorders is adolescence, a time of remarkable
physical and behavioural changes. The processes in the brain that underlie these …

Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …

Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which
is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of …

Background Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms
have been observed to show a steeper rate of cortical gray matter reduction compared with …

The lifespan of people with severe mental illness (SMI) is shorter compared to the general
population. This excess mortality is mainly due to physical illness. We report prevalence …

Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …

Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …

Personalized medicine is rapidly becoming a reality in today's physical medicine. However,
as yet this is largely an aspirational goal in psychiatry, despite significant advances in our …

Objective: Schizophrenia is a devastating mental disorder accompanied by aberrant
structural brain connectivity. The question whether schizophrenia is a progressive brain …

Progressive grey matter loss has been demonstrated among clinical high-risk (CHR)
individuals who convert to psychosis, but it is unknown whether these changes occur prior to …