IL-10 is a potent immunomodulatory cytokine that affects innate and acquired immune
responses. The immunological consequences of IL-10 production during pulmonary …

Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis in susceptible
humans. Here, we infected Diversity Outbred (DO) mice with∼ 100 bacilli by aerosol to …

Protective immunity and latent Mycobacterium tuberculosis infection in humans are
associated with the formation of mature protective granulomas within the lung. Unfortunately …

CCL5-CCR5 interactions localize protective T cells to the lungs and contribute to pulmonary
granuloma formation to control early infection with Mycobacterium tuberculosis. Control of M …

Mycobacterium tuberculosis infects two billion people across the globe, and results in 8–9
million new tuberculosis (TB) cases and 1–1.5 million deaths each year. Most patients have …

Identifying those Mycobacterium tuberculosis latent-infected individuals most at risk of
develo** active tuberculosis (TB) using routine clinical and laboratory tests remains a …

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis
(Mtb) that in most cases induces irreversible necrosis of lung tissue as a result of excessive …

To more closely understand the mechanisms of how BCG vaccination confers immunity
would help to rationally design improved tuberculosis vaccines that are urgently required …

Public concern on issues such as animal welfare or the scientific validity and clinical value of
animal research is growing, resulting in increasing regulatory demands for animal research …

During tuberculosis (TB), some Mycobacterium tuberculosis bacilli persist in the presence of
an active immunity and antibiotics that are used to treat the disease. Herein, by using the …