Regulatory mechanisms in T cell receptor signalling
The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …
intracellular signals required for T cell development, repertoire selection and effector …
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
The fate of develo** T cells is specified by the interaction of their antigen receptors with
self-peptide–MHC complexes that are displayed by thymic antigen-presenting cells (APCs) …
self-peptide–MHC complexes that are displayed by thymic antigen-presenting cells (APCs) …
CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for
antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we …
antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we …
2B4 costimulatory domain enhancing cytotoxic ability of anti-CD5 chimeric antigen receptor engineered natural killer cells against T cell malignancies
Y Xu, Q Liu, M Zhong, Z Wang, Z Chen, Y Zhang… - Journal of hematology & …, 2019 - Springer
Background Chimeric antigen receptor engineered T cells (CAR-T) have demonstrated
extraordinary efficacy in B cell malignancy therapy and have been approved by the US Food …
extraordinary efficacy in B cell malignancy therapy and have been approved by the US Food …
Thymic selection of CD4+ CD25+ regulatory T cells induced by an agonist self-peptide
MS Jordan, A Boesteanu, AJ Reed, AL Petrone… - Nature …, 2001 - nature.com
Despite accumulating evidence that regulatory T cells play a crucial role in preventing
autoimmunity, the processes underlying their generation during immune repertoire formation …
autoimmunity, the processes underlying their generation during immune repertoire formation …
[HTML][HTML] T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens
Develo** T cells express diverse antigen receptors whose specificities are not
prematched to the foreign antigens they eventually encounter. Past experiments have …
prematched to the foreign antigens they eventually encounter. Past experiments have …
[HTML][HTML] Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner
Virtual memory cells (VM) are an antigen-specific, memory phenotype CD8 T-cell subset
found in lymphoreplete, unchallenged mice. Previous studies indicated that VM cells were …
found in lymphoreplete, unchallenged mice. Previous studies indicated that VM cells were …
The self-obsession of T cells: how TCR signaling thresholds affect fate'decisions' and effector function
Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by
clonal selection to protect the host from autoimmune pathology. It is now understood that the …
clonal selection to protect the host from autoimmune pathology. It is now understood that the …
Origins and functions of B-1 cells with notes on the role of CD5
R Berland, HH Wortis - Annual review of immunology, 2002 - annualreviews.org
Whether B-1a (CD5+) cells are a distinct lineage derived from committed fetal/neonatal
precursors or arise from follicular B-2 cells in response to BCR ligation and other, unknown …
precursors or arise from follicular B-2 cells in response to BCR ligation and other, unknown …
Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis
Developmental thymic waves of innate-like and adaptive-like γδ T cells have been
described, but the current understanding of γδ T cell development is mainly limited to mouse …
described, but the current understanding of γδ T cell development is mainly limited to mouse …