Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics
owing to their natural origin, their ability to mediate intercellular communication, and their …

The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid lipid
nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest and …

Introduction and aim Olmesartan medoxomil (OLM) is an antihypertensive drug with low oral
bioavailability due to extensive first-pass metabolism. This study aimed to prepare transetho …

Bacterial endophthalmitis (BE) is a potentially sight-threatening inflammatory reaction of the
intraocular fluids or tissues caused by bacteria. Ciprofloxacin (CIP) eye drops are prescribed …

Parkinson's disease (rp) is a progressive neurodegenerative disorder. Ropinirole (RP) is a
newer generation dopamine agonist used for the treatment of PD. It is prescribed as oral …

Introduction The intention of this work was to load olmesartan medoxomil (OLM), a sparsely
water soluble antihypertensive bioactive with low oral bioavailability (26%), into PEGylated …

Ketoconazole (KZ) is a broad-spectrum imidazole antifungal agent, used in opportunistic
systemic fungal infection treatment. Gastrointestinal absorption of this drug is variable and …

Crystal engineering is an emerging tool for altering the physicochemical properties of drug
candidates. The objective of the current investigation was to develop cocrystals of …

Many new chemical entities have limited water solubility and therefore show low and/or
variable oral bioavailability. Among the various strategies to overcome this challenge …

Lyophilization is a pivotal manufacturing process to obtain a stable drug product that is
unstable as a ready-to-use formulation. Some formulations may require the addition of drug …