The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …

In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …

Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is
generally associated with drug target modification, enzymatic inactivation, and/or transport …

Directed evolution is a powerful approach for engineering biomolecules and understanding
adaptation. However, experimental strategies for directed evolution are notoriously labor …

Evolution of large asexual cell populations underlies∼ 30% of deaths worldwide, including
those caused by bacteria, fungi, parasites, and cancer. However, the dynamics underlying …

Sex and recombination are pervasive throughout nature despite their substantial costs.
Understanding the evolutionary forces that maintain these phenomena is a central …

The dynamics of adaptation determine which mutations fix in a population, and hence how
reproducible evolution will be. This is central to understanding the spectra of mutations …

Epistatic interactions between mutations can make evolutionary trajectories contingent on
the chance occurrence of initial mutations. We used experimental evolution in …

Population genetics theory supplies powerful predictions about how natural selection
interacts with genetic linkage to sculpt the genomic landscape of nucleotide polymorphism …

Does evolution proceed faster in larger or smaller populations? The relationship between
effective population size (N e) and the rate of evolution has consequences for our ability to …