The molecular pathways underlying tau pathology–induced synaptic/cognitive deficits and
neurodegeneration are poorly understood. One prevalent hypothesis is that …

The removal of skeletal muscle tension (unloading or disuse) is followed by many changes
in the neuromuscular system, including muscle atrophy and loss of isometric maximal …

Microgravity (MG) is one of the main problems that astronauts have to cope with during
space missions. Long-duration space travel can have detrimental effects on human …

Treadmill exercise is widely considered an effective strategy for restoration of skilled motor
function after spinal cord injury (SCI). However, the specific exercise intensity that optimizes …

Activity-dependent processes addressing the central nervous system (CNS) and
musculoskeletal structures are critical for maintaining motor performance. Chronic reduction …

Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic
mechanisms and associated signalling pathways have not been investigated in detail in …

Single therapeutic interventions have not yet been successful in restoring function after
spinal cord injury. Accordingly, combinatorial interventions targeting multiple factors may …

In previous studies, it has been proved that repetitive transcranial magnetic stimulation
(rTMS) improves dyskinesia induced by conditions such as spinal cord injury, Parkinson …

Isolation on Earth can alter physiology and signaling of organs systems, including the
central nervous system. Although not in complete solitude, astronauts operate in an isolated …

The long-term effects of insufficient weight loading during growth on locomotion patterns are
not fully understood. The purpose of this study was to determine 1) the effects of hindlimb …