Adaptive immune cell function is regulated by a highly diverse receptor recombined from
variable germline-encoded segments that can recognize an almost unlimited array of …

Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7-
mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the …

Immunoglobulin A (IgA) maintains commensal communities in the intestine while preventing
dysbiosis. IgA generated against intestinal microbes assures the simultaneous binding to …

Background & Aims The pathophysiology of Crohn's-like disease of the pouch (CDP) in
patients with a history of ulcerative colitis (UC) is unknown. We examined mucosal cells from …

Recent studies have investigated the role of B-cell responses in ulcerative colitis, which
exclusively affects the colon, whereas data in Crohn's disease (CD), which mainly affects the …

Crohn's disease (CD) is a prevalent type of inflammatory bowel disease (IBD) with
dysregulated antibody responses. However, there is a lack of comprehensive analysis of B …

The characteristics of ulcerative colitis (UC) in the elderly are quite different from the young
population. Mitochondrial injury is a key mechanism regulating both aging and inflammation …

Gastrointestinal (GI) B cells and plasma cells (PCs) are critical to mucosal homeostasis and
the host response to HIV-1 infection. Here, high resolution map** of human B cells and …

Precision oncology including immunotherapy with checkpoint blockers for patients with
colorectal cancer (CRC) continues to lag behind other cancer types. The immune …

Adaptive immunity, mediated by T and B cell responses, is essential for defending against
infections and cancers while also being implicated in autoimmune diseases. Tracking T and …