The genus Mycobacterium is best known for its two major pathogenic species, M.
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …

Pathogenesis by mycobacteria requires the exploitation of host-cell signalling pathways to
enhance the intracellular survival and persistence of the pathogen. The disruption of these …

The search for new TB drugs that rapidly and effectively sterilize the tissues and are thus
able to shorten the duration of chemotherapy from the current 6 months has been hampered …

The Mycobacterium tuberculosis genome contains 11 serine/threonine kinase genes
including two, pknA and pknB, that are part of an operon encoding genes involved in cell …

Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is one of the most
successful pathogens in human history. An extremely resilient cell wall and highly evolved …

The function of the Mycobacterium tuberculosis eukaryotic‐like protein serine/threonine
kinase PknG was investigated by gene knock‐out and by expression and biochemical …

Background Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a
facultative intracellular pathogen that can persist within the host. The bacteria are thought to …

A family of eukaryotic-like Ser/Thr protein kinases occurs in bacteria, but little is known about
the structures and functions of these proteins. Here we characterize PknB, a transmembrane …

The receptor-like protein kinase PknB from Mycobacterium tuberculosis is encoded by the
distal gene in a highly conserved operon, present in all actinobacteria, that may control cell …

Mycobacterium tuberculosis (M. tb) has a complex lifestyle in different environments and
involving several developmental stages. The success of M. tb results from its remarkable …