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Effect of HIV-1 subtype and tropism on treatment with chemokine coreceptor entry inhibitors; overview of viral entry inhibition
HIV-1 entry begins with viral envelope glycoprotein gp120 interacting with host-cell CD4 and
an entry coreceptor (mainly chemokine receptors CCR5 or CXCR4). Inhibitors of particular …
an entry coreceptor (mainly chemokine receptors CCR5 or CXCR4). Inhibitors of particular …
Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. Update 2011
Authorized by the Ministry of Health and Istituto Superiore di Sanità, National AIDS Centre.
In collaboration with the National AIDS Commission and the Conference of Associations for …
In collaboration with the National AIDS Commission and the Conference of Associations for …
Peptide-derivatized SB105-A10 dendrimer inhibits the infectivity of R5 and X4 HIV-1 strains in primary PBMCs and cervicovaginal histocultures
Peptide dendrimers are a class of molecules that exhibit a large array of biological effects
including antiviral activity. In this report, we analyzed the antiviral activity of the peptide …
including antiviral activity. In this report, we analyzed the antiviral activity of the peptide …
[HTML][HTML] Human immunodeficiency virus type 1 fitness and tropism: concept, quantification, and clinical relevance
M Clementi, A Lazzarin - Clinical microbiology and infection, 2010 - Elsevier
Two distinct aspects of human immunodeficiency virus type 1 (HIV-1) biopathology with
important implications for the management of treated patients have emerged during the last …
important implications for the management of treated patients have emerged during the last …
Next-generation sequencing provides an added value in determining drug resistance and viral tropism in Cameroonian HIV-1 vertically infected children
J Fokam, MC Bellocchi, D Armenia, AJ Nanfack… - Medicine, 2018 - journals.lww.com
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Recent transmission clustering of HIV-1 C and CRF17_BF strains characterized by NNRTI-related mutations among newly diagnosed men in central Italy
Background Increased evidence of relevant HIV-1 epidemic transmission in European
countries is being reported, with an increased circulation of non-B-subtypes. Here, we …
countries is being reported, with an increased circulation of non-B-subtypes. Here, we …
Impact of HIV-1 tropism on the emergence of non-AIDS events in HIV-infected patients receiving fully suppressive antiretroviral therapy
Objective: The impact of HIV-1 tropism on the emergence of non-AIDS events was evaluated
in a cohort of 116 antiretroviral therapy (ART) responder patients. Methods: The patients …
in a cohort of 116 antiretroviral therapy (ART) responder patients. Methods: The patients …
Performance of commonly used genotypic assays and comparison with phenotypic assays of HIV-1 coreceptor tropism in acutely HIV-1-infected patients
ER Ceresola, S Nozza, M Sampaolo… - Journal of …, 2015 - academic.oup.com
Objectives Although founder viruses in primary HIV-1 infections (PHIs) typically use the
CCR5 coreceptor (R5-tropic), 3%–19% of subjects also harbour CXCR4-using viruses (X4 …
CCR5 coreceptor (R5-tropic), 3%–19% of subjects also harbour CXCR4-using viruses (X4 …
Identification and structural characterization of novel genetic elements in the HIV-1 V3 loop regulating coreceptor usage
OSCAR study group, V Svicher, C Alteri… - Antiviral …, 2011 - journals.sagepub.com
Background The interaction between HIV-1 gp120 and CCR5 N terminus is critical for R5-
virus entry and affects CCR5 antagonists' activity. Knowledge of how different genetic …
virus entry and affects CCR5 antagonists' activity. Knowledge of how different genetic …
The lowest X4 Geno2Pheno false‐positive rate is associated with greater CD4 depletion in HIV‐1 infected patients
Clin Microbiol Infect Abstract Through this study we evaluated whether the HIV‐1 tropism
determined by genotypic analysis correlates with HIV‐1 markers, such as CD4 cell count …
determined by genotypic analysis correlates with HIV‐1 markers, such as CD4 cell count …