Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

Pulmonary hypertension (PH) is a progressive disease that arises from multiple etiologies
and ultimately leads to right heart failure as the predominant cause of morbidity and …

Aims Exercise confers protection against cardiovascular ageing, but the mechanisms remain
largely unknown. This study sought to investigate the role of fibronectin type-III domain …

Musculoskeletal disorders include rheumatoid arthritis, osteoarthritis, sarcopenia, injury,
stiffness, and bone loss. The prevalence of these conditions is frequent among elderly …

The causative role of inflammation in hypertension-related cardiovascular diseases is
evident and calls for development of specific immunomodulatory therapies. We tested the …

Atherosclerosis is the underlying cause for cardiovascular disease. Current
pharmacotherapies are limited by the inadequate targeting and insufficient treatment …

Carotid atherosclerotic disease continues to be an important cause of stroke, often disabling
or fatal. Such strokes could be largely prevented through optimal medical therapy and …

Although immunomodulation may be advantageous as a causal therapy in hypertension,
targeting immune networks rather than single interleukins appears of major importance …

Investigation into the role of cells with respect to extracellular matrix (ECM) remodeling is still
in its infancy. Particularly, ECM degradation is an indispensable process during the recovery …

Thoracic aortic aneurysm and dissection (TAAD) is a lethal cardiovascular condition without
effective pharmaceutical therapy. Identifying novel drugs that target the key pathogenetic …