Analyzing reaction rates with the distortion/interaction‐activation strain model
The activation strain or distortion/interaction model is a tool to analyze activation barriers that
determine reaction rates. For bimolecular reactions, the activation energies are the sum of …
determine reaction rates. For bimolecular reactions, the activation energies are the sum of …
o-Silylaryl Triflates: A Journey of Kobayashi Aryne Precursors
J Shi, L Li, Y Li - Chemical Reviews, 2021 - ACS Publications
Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …
Hexadehydro-Diels–Alder reaction: Benzyne generation via cycloisomerization of tethered triynes
The hexadehydro-Diels–Alder (HDDA) reaction is the thermal cyclization of an alkyne and a
1, 3-diyne to generate a benzyne intermediate. This is then rapidly trapped, in situ, by a …
1, 3-diyne to generate a benzyne intermediate. This is then rapidly trapped, in situ, by a …
Synthesis of biaryls using aryne intermediates
JA García-López, MF Greaney - Chemical Society Reviews, 2016 - pubs.rsc.org
The synthesis of biaryls from benzyne intermediates offers an alternative strategy to
conventional metal-catalyzed cross-coupling approaches. The concept is as old as benzyne …
conventional metal-catalyzed cross-coupling approaches. The concept is as old as benzyne …
Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products
Heterocyclic arynes, or hetarynes, have been studied for over 100 years. However,
challenges associated with observing these reactive species, as well as develo** …
challenges associated with observing these reactive species, as well as develo** …
Aryne multifunctionalization with benzdiyne and benztriyne equivalents
J Shi, Y Li, Y Li - Chemical Society Reviews, 2017 - pubs.rsc.org
One of the most distinct characters of aryne chemistry over other synthetic methodologies is
its ability to simultaneously functionalize the vicinal two positions of a benzene ring with …
its ability to simultaneously functionalize the vicinal two positions of a benzene ring with …
The renaissance and bright future of synthetic aryne chemistry
Recent developments in aryne chemistry are reviewed with a particular focus on synthetic
methods. This includes an overview of the precursors of arynes and their activators; the …
methods. This includes an overview of the precursors of arynes and their activators; the …
On-surface generation and imaging of arynes by atomic force microscopy
Reactive intermediates are involved in many chemical transformations. However, their
characterization is a great challenge because of their short lifetimes and high reactivities …
characterization is a great challenge because of their short lifetimes and high reactivities …
Strategies toward aryne multifunctionalization via 1, 2-benzdiyne and benzyne
J He, D Qiu, Y Li - Accounts of Chemical Research, 2020 - ACS Publications
Conspectus Polysubstituted arenes are prevalent in numerous natural products, medicines,
agrochemicals, and organic functional materials. Among methods to prepare polysubstituted …
agrochemicals, and organic functional materials. Among methods to prepare polysubstituted …
Functionalization of o-carboranes via carboryne intermediates
Z Qiu, Z **e - Chemical Society Reviews, 2022 - pubs.rsc.org
Carborynes (1, 2-dehydro-o-carborane and 1, 3-dehydro-o-carborane), three-dimensional
analogues of benzyne, can be generated in situ from the precursors 1-X-2-Li-1, 2 …
analogues of benzyne, can be generated in situ from the precursors 1-X-2-Li-1, 2 …