The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

The liver is a large highly vascularized organ with a central function in metabolic
homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to …

Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be
cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past …

Matrix metalloproteinases (MMPs) 9 and 2 are increased in human abdominal aortic
aneurysm (AAA) tissue, but their precise role and potential interaction remain unclear …

Cancer cells often develop resistance to chemotherapy or irradiation through mutations in
the p53 tumour-suppressor gene, which prevent apoptosis induction in response to cellular …

Matrix metalloproteinases (MMPs) are a large family of zinc-endopeptidases which play
important roles in multiple physiological and pathological processes. These enzymes are …

The hepatocyte is especially vulnerable to injury due to its central role in xenobiotic
metabolism including drugs and alcohol, participation in lipid and fatty acid metabolism, its …

Matrix metalloproteinases (MMPs) have outgrown the field of extracellular-matrix biology
and have progressed towards being important regulatory molecules in cancer and …

α1-Acid glycoprotein (AGP) is a protein with a molecular weight of 41–43kDa and is heavily
glycosylated (45%). Due to the presence of sialic acids, it is negatively charged (pI= 2.7 …

The matrix metalloproteinases (MMP)-2 and-9, also known as the gelatinases have been
long recognized as major contributors to the proteolytic degradation of extracellular matrix …