Chagas disease, a neglected disease caused by the protozoan Trypanosoma cruzi, is
endemic in 21 Latin American countries, affecting 6–8 million people. Increasing numbers of …

Introduction Chronic infection with the protozoal parasite Trypanosoma cruzi leads to a
progressive cardiac disease, known as chronic Chagasic cardiomyopathy (CCC). A new …

Chagas disease is a chronic infection caused by Trypanosoma cruzi, an intracellular
protozoan parasite. Chronic chagasic patients (CCPs) have dysfunctional CD8+ T cells that …

Chagas disease (ChD), a complex and persistent parasitosis caused by Trypanosoma cruzi,
represents a natural model of chronic infection, in which some people exhibit cardiac or …

The CD4+ and CD8+ T cell immune response against T. cruzi, the parasite causing Chagas
disease, are relevant for both parasite control and disease pathogenesis. Several studies …

Monocytes are classified according to their CD14 and CD16 expression into classical
(reparative), intermediate (inflammatory), and non-classical. This study assessed the …

The protozoan Trypanosoma cruzi is the causative agent of Chagas' disease, endemic in
Latin America but present worldwide. Research efforts have focused on the examination of …

The host immunological response is a key factor determining the pathogenesis of cutaneous
leishmaniasis. It is known that a Th1 cellular response is associated with infection control …

Trypanosoma cruzi infection is characterized by chronic parasitism of non-lymphoid tissues
and is rarely eliminated despite potent adaptive immune responses. This failure to cure has …

Background Patients with chronic Chagas disease present marked clinical and
immunological heterogeneity. During the disease, multiple immune mechanisms are …