From purines to purinergic signalling: molecular functions and human diseases
Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …
Getting to the outer leaflet: physiology of phosphatidylserine exposure at the plasma membrane
EM Bevers, PL Williamson - Physiological reviews, 2016 - journals.physiology.org
Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …
distribution between inner and outer leaflets is an important physiological signal. Normally …
P2X7 interactions and signaling–making head or tail of it
Extracellular adenine nucleotides play important roles in cell–cell communication and tissue
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …
ATP synthesis and storage
Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the
knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell …
knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell …
Single domain antibodies: promising experimental and therapeutic tools in infection and immunity
J Wesolowski, V Alzogaray, J Reyelt, M Unger… - Medical microbiology …, 2009 - Springer
Antibodies are important tools for experimental research and medical applications. Most
antibodies are composed of two heavy and two light chains. Both chains contribute to the …
antibodies are composed of two heavy and two light chains. Both chains contribute to the …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …
performing flow cytometry experiments and includes comprehensive sections describing …
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
ADP-ribosylation, a multifaceted posttranslational modification involved in the control of cell physiology in health and disease
B Lüscher, M Bütepage, L Eckei, S Krieg… - Chemical …, 2018 - ACS Publications
Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
Purine release, metabolism, and signaling in the inflammatory response
ATP, NAD+, and nucleic acids are abundant purines that, in addition to having critical
intracellular functions, have evolved extracellular roles as danger signals released in …
intracellular functions, have evolved extracellular roles as danger signals released in …
Purinergic signalling and immune cells
This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …
regulation of various subsets of immune cells from early discoveries to current …