Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …

Aging is a complex biological process and represents the largest risk factor for
neurodegenerative disorders. The risk for neurodegenerative disorders is also increased in …

The molecular organization of the human neocortex historically has been studied in the
context of its histological layers. However, emerging spatial transcriptomic technologies …

Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the
brain. Yet little is understood about how genetic variants influence cell-level gene …

The genetic basis of schizophrenia (SZ) remains elusive despite its characterization as a
highly heritable disorder. This incomplete understanding has led to stagnation in …

Generation of a molecular neuroanatomical map of the human prefrontal cortex reveals
novel spatial domains and cell-cell interactions relevant for psychiatric disease. The …

Objective: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major
depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease …

A meta-genome-wide association study across eight psychiatric disorders has highlighted
the genetic architecture of pleiotropy in major psychiatric disorders. However, mechanisms …

The omnigenic model posits that genetic risk for traits with complex heritability involves
cumulative effects of peripheral genes on mechanistic" core genes," suggesting that in a …

Sample-wise deconvolution methods estimate cell-type proportions and gene expressions
in bulk tissue samples, yet their performance and biological applications remain unexplored …