The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

The cell orchestrates the dance of chromosome segregation with remarkable speed and
fidelity. The mitotic spindle is built from scratch after interphase through microtubule (MT) …

Light-sheet microscopes enable rapid high-resolution imaging of biological specimens;
however, biological processes span spatiotemporal scales. Moreover, long-term phenotypes …

The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …

Mitotic spindle assembly is crucial for chromosome segregation and relies on bundles of
microtubules that extend from the poles and overlap in the middle. However, how these …

The γ-tubulin ring complex (γ-TuRC) has essential roles in centrosomal and non-
centrosomal microtubule organization during vertebrate mitosis. While there have been …

Chromosome segregation in mammals relies on the maturation of a thick bundle of
kinetochore-attached microtubules known as k-fiber. How k-fibers mature from initial …

During cell division, chromosome congression to the spindle center, their orientation along
the spindle long axis and alignment at the metaphase plate depend on interactions between …

Error correction is central to many biological systems and is critical for protein function and
cell health. During mitosis, error correction is required for the faithful inheritance of genetic …

The spindle is a bipolar microtubule-based machine that is crucial for accurate chromosome
segregation. Spindle bipolarity is generated by Eg5 (a kinesin-5), a conserved motor that …