The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Epigenetic modifications, including posttranslational modifications of histones, are closely
linked to transcriptional regulation. Trimethylated H3 lysine 4 (H3K4me3) is one of the most …

The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal
region of genes. Previous work has shed light on how Integrator binds to the paused …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system with the
worst prognosis. Even after radical surgery, the majority of patients with GBC have difficulty …

Background Pulmonary hypertension (PH) is a complex vascular disorder, characterized by
pulmonary vessel remodeling and perivascular inflammation. Pulmonary arterial smooth …

Eukaryotic genomes are widely transcribed by RNA polymerase II (pol II) both within genes
and in intergenic regions. POL II elongation complexes comprising the polymerase, the DNA …

INTS11 and CPSF73 are metal-dependent endonucleases for Integrator and pre-mRNA 3′-
end processing, respectively. Here, we show that the INTS11 binding partner …

The metazoan-specific Integrator complex catalyzes 3′ end processing of small nuclear
RNAs (snRNAs) and premature termination that attenuates the transcription of many protein …

RNA polymerase II progression from initiation to elongation is driven in part by a cascade of
protein kinases acting on the core transcription machinery. Conversely, the corresponding …