The extensive lengths of neuronal processes necessitate efficient mechanisms for
communication with the cell body. Neuronal regeneration after nerve injury requires new …

Injury to axons elicits changes in macromolecule synthesis in the corresponding cell bodies
that are critical for an effective regenerative response. For decades the most easily studied …

Neurons differ in their responses to injury, but the underlying mechanisms remain poorly
understood. Using quantitative proteomics, we characterized the injury-triggered response …

Regeneration of injured neurons can restore function, but most neurons regenerate poorly
or not at all. The failure to regenerate in some cases is due to a lack of activation of cell …

How are phosphorylated kinases transported over long intracellular distances, such as in
the case of axon to cell body signaling after nerve injury? Here, we show that the MAP …

Growth cone guidance and synaptic plasticity involve dynamic local changes in proteins at
axons and dendrites. The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously …

Axoplasmic proteins containing nuclear localization signals (NLS) signal retrogradely by an
unknown mechanism in injured nerve. Here we demonstrate that the importin/karyopherin α …

Neurons transmit long-range biochemical signals between cell bodies and distant axonal
sites or termini. To test the hypothesis that signaling molecules are hitchhikers on axonal …

Cleavage fragments of de novo synthesized vimentin were recently reported to interact with
phosphorylated Erk1 and Erk2 MAP kinases (pErk) in injured sciatic nerve, thus linking pErk …

In the present study, we investigated if the previously observed JNK-mediated activation of c-
Jun and induction of ATF3 could be ascribed to axonal transport of JNK signaling …