Tuberculosis (TB) remains a serious threat to global public health, responsible for an
estimated 1.5 million mortalities in 2018. While there are available therapeutics for this …

The outbreak of acute respiratory disease in 2019, namely Coronavirus Disease-2019
(COVID-19), has become an unprecedented healthcare crisis. To mitigate the pandemic …

In the present study, novel bis‐Schiff base derivatives of polyhydroquinoline were
synthesized through Hantzsch condensation reaction in excellent yields. Initially, a mixture …

Diabetes mellitus is a chronic metabolic disorder that affects more than 180 million people
worldwide. Peroxisome proliferator activated receptors (PPARs) are a group of nuclear …

The impact of two extraction solvents on the phenolic composition, antioxidant, and enzymes
inhibitory and antimicrobial activities of two parts (leaves and stem bark) of P. kotschyi was …

Peptides are preferred for designing inhibitors because of their high activity and specificity.
Seven cyclopentapeptide inhibitors were designed in this study against dengue virus type 2 …

Ritonavir is a BCS class II antiretroviral agent which shows poor aqueous solubility and low
oral bioavailability. The cocrystallization approach was selected to overcome these …

Mycobacterium and Corynebacterium are important genera of the Corynebacteriales order,
the members of which are characterized by an atypical diderm cell envelope. Indeed the …

A series of new heterocycles (4–18) was synthesized by the structural modification of
benzimidazole‐2‐thiol (BT, 2‐MBI). The structures of the synthesized compounds were …

We have recently reported G-protein coupled receptor (GPCR) model structures for the
active and inactive states of the human dopamine D2 receptor (D2R) using adrenergic …