Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …

Cell death in neurodegenerative diseases is often thought to be governed by apoptosis;
however, an increasing body of evidence suggests the involvement of alternative cell death …

Inherited retinal degeneration (RD) is a devastating and currently untreatable
neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The …

Retinitis pigmentosa is a group of hereditary retinal dystrophies that normally result in
photoreceptor cell death and vision loss both in animal models and in affected patients. The …

Photoreceptors in the retina are highly specialized neurons with photosensitive molecules in
the outer segment that transform light into chemical and electrical signals, and these signals …

Ion channels are membrane-spanning integral proteins expressed in multiple organs,
including the eye. Here, ion channels play a role in several physiological processes, like …

The retinal degeneration model rd10 contains a missense mutation of the catalytic PDE6 β
subunit, which hydrolyzes cGMP in response to light. This model produces cell death more …

The second messengers, cGMP and Ca 2+, have both been implicated in retinal
degeneration; however, it is still unclear which of the two is most relevant for photoreceptor …

Calcium plays important roles in the function and survival of rod and cone photoreceptor
cells. Rapid regulation of calcium in the outer segments of photoreceptors is required for the …