Articular cartilage is a physiologically non-self-renewing avascular tissue with a unique cell
type, the chondrocyte, which functions as producing and maintaining the extracellular matrix …

The identification of the Drosophila homolog of the human MYC oncogene has fostered a
series of studies aimed to address its functions in development and cancer biology. Due to …

Colorectal carcinoma (CRC) is the third most prevalent cancer, causing a significant
mortality worldwide. Present available therapies are surgery, chemotherapy including …

Inhibition of the androgen receptor (AR) is the main strategy to treat advanced prostate
cancers. AR-independent treatment-resistant prostate cancer is a major unresolved clinical …

Overactivation of the WNT/β-CATENIN signaling axis is a common denominator in colorectal
cancer. Currently, there is no available WNT inhibitor in clinical practice. Although …

Pancreatic fibrosis, a prominent feature of chronic pancreatitis (CP), induces persistent and
permanent damage in the pancreas. Pancreatic stellate cells (PSCs) provide a major source …

Research in the human genome sciences generates a substantial amount of genetic data for
hundreds of thousands of individuals, which concomitantly increases the number of variants …

Regulator of G protein signaling z1 (RGSz1), a member of the RGS family of proteins, is
present in several networks expressing mu opioid receptors (MOPRs). By using genetic …

Embryonic genome activation (EGA) is orchestrated by an intrinsic developmental program
initiated during oocyte maturation with translation of stored maternal mRNAs. Here, we show …

AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating
cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has …