Simple Summary Cisplatin is a chemotherapy drug widely used in the treatment of different
cancer types. However, cisplatin displays a high range of toxicity and its use usually leads to …

Protein lysine methyltransferases (PKMTs) play crucial roles in histone and nonhistone
modifications, and their dysregulation has been linked to the development and progression …

While screening and early detection have reduced mortality from prostate cancer, castration-
resistant disease (CRPC) is still incurable. Here, we report that combined EZH2/HDAC …

Extracellular vesicles (EVs) secreted by tumors are abundant in plasma, but their potential
for interrogating the molecular features of tumors through multi-omic profiling remains widely …

Abstract Enhancer of Zeste Homolog 2 (EZH2) and androgen receptor (AR) are crucial
chromatin/gene regulators involved in the development and/or progression of prostate …

DNA repair dysregulation is a key driver of cancer development. Understanding the
molecular mechanisms underlying DNA repair dysregulation in cancer cells is crucial for …

Recurrent somatic mutations in the BRG1/BRM-associated factor (BAF) chromatin
remodeling complex subunit ARID1A occur frequently in advanced urothelial, endometrial …

Osteoarthritis (OA) is a prevalent joint disease with no effective treatment strategies.
Aberrant mechanical stimuli was demonstrated to be an essential factor for OA …

Summary Background The E1A-associated protein p300 (p300) has emerged as a
promising target for cancer therapy due to its crucial role in promoting oncogenic signaling …

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and emerging
therapeutic target that is overexpressed in most castration-resistant prostate cancers and …