[HTML][HTML] Antimicrobial peptides for combating drug-resistant bacterial infections

J Xuan, W Feng, J Wang, R Wang, B Zhang, L Bo… - Drug Resistance …, 2023 - Elsevier
The problem of drug resistance due to long-term use of antibiotics has been a concern for
years. As this problem grows worse, infections caused by multiple bacteria are expanding …

Antimicrobial peptides: Application informed by evolution

BP Lazzaro, M Zasloff, J Rolff - Science, 2020 - science.org
BACKGROUND Antimicrobial peptides (AMPs) are small proteins with potent antibacterial,
antiviral, and antifungal activity. AMPs are ubiquitous among multicellular eukaryotes, with …

Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

REW Hancock, HG Sahl - Nature biotechnology, 2006 - nature.com
Short cationic amphiphilic peptides with antimicrobial and/or immunomodulatory activities
are present in virtually every life form, as an important component of (innate) immune …

Designing antimicrobial peptides: form follows function

CD Fjell, JA Hiss, REW Hancock… - Nature reviews Drug …, 2012 - nature.com
Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …

[HTML][HTML] Mechanisms and consequences of bacterial resistance to antimicrobial peptides

DI Andersson, D Hughes… - Drug Resistance Updates, 2016 - Elsevier
Cationic antimicrobial peptides (AMPs) are an intrinsic part of the human innate immune
system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial …

The fitness costs of antibiotic resistance mutations

AH Melnyk, A Wong, R Kassen - Evolutionary applications, 2015 - Wiley Online Library
Antibiotic resistance is increasing in pathogenic microbial populations and is thus a major
threat to public health. The fate of a resistance mutation in pathogen populations is …

Experimental evolution

TJ Kawecki, RE Lenski, D Ebert, B Hollis… - Trends in ecology & …, 2012 - cell.com
Experimental evolution is the study of evolutionary processes occurring in experimental
populations in response to conditions imposed by the experimenter. This research approach …

Antimicrobial peptides: key components of the innate immune system

M Pasupuleti, A Schmidtchen… - Critical reviews in …, 2012 - Taylor & Francis
Life-threatening infectious diseases are on their way to cause a worldwide crisis, as treating
them effectively is becoming increasingly difficult due to the emergence of antibiotic resistant …

Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health

T Li, Z Wang, J Guo, C de la Fuente-Nunez… - Science of The Total …, 2023 - Elsevier
The spread of bacterial drug resistance has posed a severe threat to public health globally.
Here, we cover bacterial resistance to current antibacterial drugs, including traditional herbal …

The co-evolution of host cationic antimicrobial peptides and microbial resistance

A Peschel, HG Sahl - Nature Reviews Microbiology, 2006 - nature.com
Endogenous cationic antimicrobial peptides (CAMPs) are among the most ancient and
efficient components of host defence. It is somewhat of an enigma that bacteria have not …