Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …

The past few decades have witnessed an evolution of nanomedicine from biologically inert
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …

The impermeable barrier of solid tumors due to the complexity of their components limits the
treatment effect of nanomedicine and hinders its clinical translation. Several methods are …

Cationic liposomes (CLs) have been regarded as the most promising gene delivery vectors
for decades with the advantages of excellent biodegradability, biocompatibility, and high …

Nanocarriers have been widely employed in preclinical studies and clinical trials for the
delivery of anticancer drugs. The most important causes of failure in clinical translation of …

Tumor penetration is important for effectively tumor targeting drug delivery. Recently, many
researches are published to overcome the barriers that restrict tumor penetration and …

New evidence suggests that the mechanism of nanoparticle entry into solid tumours may be
driven by an active process. This insight paves the way for approaches to enhance the …

The dense fibrotic stroma in pancreatic ductal adenocarcinoma (PDA) resists drug diffusion
into the tumor and leads to an unsatisfactory prognosis. To address this problem, we …

Liposomes are the first and mostly explored nanocarriers for cancer drug delivery, which
have shown great promise in clinical applications, but their limited accumulation and …

Cancer nanomedicine is one of the most promising domains that has emerged in the
continuing search for cancer diagnosis and treatment. The rapid development of …