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Canalization reduces the nonlinearity of regulation in biological networks
Biological networks, such as gene regulatory networks, possess desirable properties. They
are more robust and controllable than random networks. This motivates the search for …
are more robust and controllable than random networks. This motivates the search for …
Cancer mutationscape: revealing the link between modular restructuring and intervention efficacy among mutations
D Plaugher, D Murrugarra - NPJ Systems Biology and Applications, 2024 - nature.com
There is increasing evidence that biological systems are modular in both structure and
function. Complex biological signaling networks such as gene regulatory networks (GRNs) …
function. Complex biological signaling networks such as gene regulatory networks (GRNs) …
Integrative in silico approaches to analyse microRNA‐mediated responses in human diseases
M Agrawal, A Mani - The Journal of Gene Medicine, 2024 - Wiley Online Library
Advancements in sequencing technologies have facilitated omics level information
generation for various diseases in human. High‐throughput technologies have become a …
generation for various diseases in human. High‐throughput technologies have become a …
Life's building blocks: the modular path to multiscale complexity
Modularity, the structuring of systems into discrete, interconnected units, is a fundamental
organizing principle in biology across multiple scales. Recent progress in understanding the …
organizing principle in biology across multiple scales. Recent progress in understanding the …
Pancreatic cancer mutationscape: revealing the link between modular restructuring and intervention efficacy amidst common mutations
D Plaugher, D Murrugarra - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
There is increasing evidence that biological systems are modular in both structure and
function. Complex biological signaling networks such as gene regulatory networks (GRNs) …
function. Complex biological signaling networks such as gene regulatory networks (GRNs) …
Beyond Boolean networks: new tools for the steady state analysis of multivalued networks
JG Galofre, MP Millán, AG Rial… - arxiv preprint arxiv …, 2024 - arxiv.org
Boolean networks can be viewed as functions on the set of binary strings of a given length,
described via logical rules. They were introduced as dynamic models into biology, in …
described via logical rules. They were introduced as dynamic models into biology, in …
Modular construction of Boolean networks
Boolean networks have been used in a variety of settings, as models for general complex
systems as well as models of specific systems in diverse fields, such as biology …
systems as well as models of specific systems in diverse fields, such as biology …
Modular control of Boolean network models
The concept of control is crucial for effectively understanding and applying biological
network models. Key structural features relate to control functions through gene regulation …
network models. Key structural features relate to control functions through gene regulation …
Learning dynamic representations of the functional connectome in neurobiological networks
The static synaptic connectivity of neuronal circuits stands in direct contrast to the dynamics
of their function. As in changing community interactions, different neurons can participate …
of their function. As in changing community interactions, different neurons can participate …
[PDF][PDF] Multiscale Information Processing in the Immune System
R Navarro-Quiroz, JV Camacho, EZ Peñata… - 2025 - preprints.org
The immune system is a dynamic network that processes information across multiple
biological scales, from molecular recognition of antigens to systemic coordination with the …
biological scales, from molecular recognition of antigens to systemic coordination with the …