Cell2location maps fine-grained cell types in spatial transcriptomics
Spatial transcriptomic technologies promise to resolve cellular wiring diagrams of tissues in
health and disease, but comprehensive map** of cell types in situ remains a challenge …
health and disease, but comprehensive map** of cell types in situ remains a challenge …
A review of spatial profiling technologies for characterizing the tumor microenvironment in immuno-oncology
Interpreting the mechanisms and principles that govern gene activity and how these genes
work according to-their cellular distribution in organisms has profound implications for …
work according to-their cellular distribution in organisms has profound implications for …
Transcriptional spatial profiling of cancer tissues in the era of immunotherapy: the potential and promise
SN Nerurkar, D Goh, CCL Cheung, PQY Nga, JCT Lim… - Cancers, 2020 - mdpi.com
Simple Summary In recent years, immunotherapy has emerged as a pillar in the fight against
cancer. However, the heterogeneity within the tumor microenvironment poses challenges to …
cancer. However, the heterogeneity within the tumor microenvironment poses challenges to …
Comprehensive map** of tissue cell architecture via integrated single cell and spatial transcriptomics
The spatial organization of cell types in tissues fundamentally shapes cellular interactions
and function, but the high-throughput spatial map** of complex tissues remains a …
and function, but the high-throughput spatial map** of complex tissues remains a …
[HTML][HTML] Single cell derived mRNA signals across human kidney tumors
Tumor cells may share some patterns of gene expression with their cell of origin, providing
clues into the differentiation state and origin of cancer. Here, we study the differentiation …
clues into the differentiation state and origin of cancer. Here, we study the differentiation …
Cell Atlas technologies and insights into tissue architecture
A Wilbrey-Clark, K Roberts… - Biochemical …, 2020 - portlandpress.com
Since Robert Hooke first described the existence of 'cells' in 1665, scientists have sought to
identify and further characterise these fundamental units of life. While our understanding of …
identify and further characterise these fundamental units of life. While our understanding of …
Ultra high-plex spatial proteogenomic investigation of giant cell glioblastoma multiforme immune infiltrates reveals distinct protein and RNA expression profiles
SA Bonnett, AB Rosenbloom, GT Ong, M Conner… - Cancer Research …, 2023 - AACR
A deeper understanding of complex biological processes, including tumor development and
immune response, requires ultra high-plex, spatial interrogation of multiple “omes”. Here we …
immune response, requires ultra high-plex, spatial interrogation of multiple “omes”. Here we …
Disruption of perinatal myeloid niches impacts the aging clock of pancreatic β cells
J O'Sell, V Cirulli, S Pardike, M Aare-Bentsen, P Sdek… - Iscience, 2024 - cell.com
Perinatal expansion of pancreatic β cells is critical to metabolic adaptation. Yet, mechanisms
surveying the fidelity by which proliferative events generate functional β cell pools remain …
surveying the fidelity by which proliferative events generate functional β cell pools remain …
Minimal mRNA uptake and inflammatory response to COVID-19 mRNA vaccine exposure in human placental explants
Despite universal recommendations for COVID-19 mRNA vaccination in pregnancy, uptake
has been lower than desired. There have been limited studies of the direct impact of COVID …
has been lower than desired. There have been limited studies of the direct impact of COVID …
Analysis of Spatial Molecular Data
A Levy-Jurgenson, X Tekpli, VN Kristensen… - … : Methods and Protocols, 2023 - Springer
Digital analysis of pathology whole-slide images has been recently gaining interest in the
context of cancer diagnosis and treatment. In particular, deep learning methods have …
context of cancer diagnosis and treatment. In particular, deep learning methods have …