The “entourage effect”: terpenes coupled with cannabinoids for the treatment of mood disorders and anxiety disorders
Mood disorders are the most prevalent mental conditions encountered in psychiatric
practice. Numerous patients suffering from mood disorders present with treatment-resistant …
practice. Numerous patients suffering from mood disorders present with treatment-resistant …
From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus
Endocannabinoids (eCBs) exert major control over neuronal activity by activating
cannabinoid receptors (CBRs). The functionality of the eCB system is primarily ascribed to …
cannabinoid receptors (CBRs). The functionality of the eCB system is primarily ascribed to …
[HTML][HTML] Endocannabinoid-mediated control of synaptic transmission
M Kano, T Ohno-Shosaku… - Physiological …, 2009 - journals.physiology.org
The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …
Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder
Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …
The molecular logic of endocannabinoid signalling
D Piomelli - Nature Reviews Neuroscience, 2003 - nature.com
The endocannabinoids are a family of lipid messengers that engage the cell surface
receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana …
receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana …
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
To understand the functional significance and mechanisms of action in the CNS of
endogenous and exogenous cannabinoids, it is crucial to identify the neural elements that …
endogenous and exogenous cannabinoids, it is crucial to identify the neural elements that …
[HTML][HTML] 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain
Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
Epidemiological studies have documented a reduced prevalence of Alzheimer's disease
among users of nonsteroidal anti-inflammatory drugs (NSAIDs),,,,. It has been proposed that …
among users of nonsteroidal anti-inflammatory drugs (NSAIDs),,,,. It has been proposed that …
The emerging role of the endocannabinoid system in endocrine regulation and energy balance
During the last few years, the endocannabinoid system has emerged as a highly relevant
topic in the scientific community. Many different regulatory actions have been attributed to …
topic in the scientific community. Many different regulatory actions have been attributed to …