[HTML][HTML] The role of CD71+ erythroid cells in the regulation of the immune response
Complex regulation of the immune response is necessary to support effective defense of an
organism against hostile invaders and to maintain tolerance to harmless microorganisms …
organism against hostile invaders and to maintain tolerance to harmless microorganisms …
Hematopoietic responses to SARS-CoV-2 infection
S Elahi - Cellular and Molecular Life Sciences, 2022 - Springer
Under physiological conditions, hematopoietic stem and progenitor cells (HSPCs) in the
bone marrow niches are responsible for the highly regulated and interconnected …
bone marrow niches are responsible for the highly regulated and interconnected …
Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis
C Xu, J He, H Wang, Y Zhang, J Wu, L Zhao, Y Li… - Nature …, 2022 - nature.com
Nonimmune cells can have immunomodulatory roles that contribute to healthy development.
However, the molecular and cellular mechanisms underlying the immunomodulatory …
However, the molecular and cellular mechanisms underlying the immunomodulatory …
Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2
SARS-CoV-2 infection is associated with lower blood oxygen levels, even in patients without
hypoxia requiring hospitalization. This discordance illustrates the need for a more unifying …
hypoxia requiring hospitalization. This discordance illustrates the need for a more unifying …
The quality of SARS-CoV-2–specific T cell functions differs in patients with mild/moderate versus severe disease, and T cells expressing coinhibitory receptors are …
Understanding the function of SARS-CoV-2 Ag-specific T cells is crucial for the monitoring of
antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is …
antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is …
CD71+ Erythroid Cells in Human Neonates Exhibit Immunosuppressive Properties and Compromise Immune Response Against Systemic Infection in Neonatal Mice
Newborns are highly susceptible to infectious diseases. The underlying mechanism of
neonatal infection susceptibility has generally been related to their under-developed …
neonatal infection susceptibility has generally been related to their under-developed …
[HTML][HTML] CD71+ erythroid cells suppress T-cell effector functions and predict immunotherapy outcomes in patients with virus-associated solid tumors
N Bozorgmehr, I Okoye, S Mashhouri, J Lu… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer.
However, only a portion of patients respond to such treatments. Therefore, it remains a …
However, only a portion of patients respond to such treatments. Therefore, it remains a …
Differential impact of SARS-CoV-2 isolates, namely, the Wuhan Strain, Delta, and Omicron variants on erythropoiesis
ABSTRACT SARS-CoV-2 variants exhibit different viral transmissibility and disease severity.
However, their impact on erythropoiesis has not been investigated. Here, we show SARS …
However, their impact on erythropoiesis has not been investigated. Here, we show SARS …
[HTML][HTML] Neutrophils promote T-cell activation through the regulated release of CD44-bound Galectin-9 from the cell surface during HIV infection
The interaction of neutrophils with T cells has been the subject of debate and controversies.
Previous studies have suggested that neutrophils may suppress or activate T cells. Despite …
Previous studies have suggested that neutrophils may suppress or activate T cells. Despite …
Transcriptomic profiling of peripheral blood cells in HPV‐associated carcinoma patients receiving combined valproic acid and avelumab
N Bozorgmehr, H Syed, S Mashhouri… - Molecular …, 2024 - Wiley Online Library
Human papillomavirus (HPV)‐associated cancer continues to evade the immune system by
promoting a suppressive tumor microenvironment. Therefore, immunotherapy appears to be …
promoting a suppressive tumor microenvironment. Therefore, immunotherapy appears to be …