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[HTML][HTML] Mechanisms of long COVID and the path toward therapeutics
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …
The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been
defined as the greatest global health and socioeconomic crisis of modern times. While most …
defined as the greatest global health and socioeconomic crisis of modern times. While most …
Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment
C Greene, R Connolly, D Brennan, A Laffan… - Nature …, 2024 - nature.com
Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19)
pathogenesis and may predispose to the neurological sequelae associated with long …
pathogenesis and may predispose to the neurological sequelae associated with long …
Large-scale phenoty** of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
F Liew, C Efstathiou, S Fontanella, M Richardson… - Nature …, 2024 - nature.com
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged
symptoms termed long coronavirus disease (COVID), yet disease phenotypes and …
symptoms termed long coronavirus disease (COVID), yet disease phenotypes and …
[HTML][HTML] Fibrin drives thromboinflammation and neuropathology in COVID-19
Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19
and are persistent in patients with long COVID experiencing post-acute sequelae of SARS …
and are persistent in patients with long COVID experiencing post-acute sequelae of SARS …
Sepsis-trained macrophages promote antitumoral tissue-resident T cells
A Broquet, V Gourain, T Goronflot, V Le Mabecque… - Nature …, 2024 - nature.com
Sepsis induces immune alterations, which last for months after the resolution of illness. The
effect of this immunological reprogramming on the risk of develo** cancer is unclear. Here …
effect of this immunological reprogramming on the risk of develo** cancer is unclear. Here …
[HTML][HTML] Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
M Taquet, Z Skorniewska, T De Deyn… - The Lancet …, 2024 - thelancet.com
Background COVID-19 is known to be associated with increased risks of cognitive and
psychiatric outcomes after the acute phase of disease. We aimed to assess whether these …
psychiatric outcomes after the acute phase of disease. We aimed to assess whether these …
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction
GK Wood, BF Sargent, ZUA Ahmad, K Tharmaratnam… - Nature medicine, 2025 - nature.com
The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19
cognitive deficits are unknown, limiting our ability to develop prevention and treatment …
cognitive deficits are unknown, limiting our ability to develop prevention and treatment …
Translating insights into therapies for Long Covid
AAR Antar, AL Cox - Science translational medicine, 2024 - science.org
Long Covid is defined by a wide range of symptoms that persist after the acute phase of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly …
Brain and cognitive changes in patients with long COVID compared with infection-recovered control subjects
VM Serrano del Pueblo, G Serrano-Heras… - Brain, 2024 - academic.oup.com
Abstract Between 2.5% and 28% of people infected with SARS-CoV-2 suffer long COVID or
persistence of symptoms for months after acute illness. Many symptoms are neurological …
persistence of symptoms for months after acute illness. Many symptoms are neurological …