Animal embryos need to specify different cell types, and the genetic functions that provide
such controls are easy to comprehend since they result in the formation of overtly …

Morphogens are long-range signaling molecules that pattern develo** tissues in a
concentration-dependent manner. The graded activity of morphogens within tissues …

The maternal gene bicoid (bcd) organizes anterior development in Drosophila. Its mRNA is
localized at the anterior tip of the oocyte and early embryo. Antibodies raised against bcd …

The metameric organization of the Drosophila embryo is generated in the first 5 h after
fertilization. An initially rather simple pattern provides the foundation for subsequent …

We demonstrate that conditional ablation of the homeobox transcription factor Cdx2 from
early endoderm results in the replacement of the posterior intestinal epithelium with …

The principles of pattern formation in embryogenesis can be studied in Drosophila by means
of a powerful combination of genetic and transplantation experiments. The segmented …

The body plan of Drosophila is determined to a large extent by homeotic genes, which
specify the identity and spatial arrangement of the body segments. Homeotic genes share a …

'Homeotic'transformations are developmental anomalies in which one part of the body
develops iiJ the likeness of another. Many cases of homeosis were described and the …

Three mouse homologues of the Drosophila homeotic gene Caudal (Cad) have been
described. They are currently designated Cdx‐1, Cdx‐2, and Cdx‐4. Cdx‐1 and 2 are both …

In Drosophila the process of segmentation depends on the function of coordinate, gap, pair‐
rule and segment‐polarity genes. Mutations in segment‐polarity genes cause defects in the …