Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an
important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage …

Gelatin methacrylate (GelMA) hydrogels have gained significant traction in diverse tissue
engineering applications through the utilization of 3D printing technology. As an artificial …

3D printing of biological tissues has been of increasing interest to the biomaterials
community in part because of its potential to produce spatially heterogeneous constructs …

The exceptional mechanical properties of the load-bearing connection of tendon to bone
rely on an intricate interplay of its biomolecular composition, microstructure and …

Articular cartilage is comprised of zones that vary in architecture, extracellular matrix
composition, and mechanical properties. Here, we designed and engineered a porous zonal …

Osteoarthritis is a complex disease involving the mechanical breakdown of articular
cartilage in the presence of altered joint mechanics and chondrocyte death, but the …

Limited regeneration capacity of cartilage can be addressed by tissue engineering
approaches including localized delivery of bioactive agents using biomaterials. Although …

Nanoindentation techniques, with high spatial resolution and force sensitivity, have recently
been moved into the center of the spotlight for measuring the mechanical properties of …

Articular cartilage is integral to the mechanical function of many joints in the body. When
injured, cartilage lacks the capacity to self-heal, and thus, therapies and replacements have …

Fine-tuning of bio-ink composition and material processing parameters is crucial for the
development of biomechanically relevant cartilage constructs. This study aims to design and …