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Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management
The discoveries of EGFR mutations and ALK rearrangements as actionable oncogenic
drivers in non-small-cell lung cancer (NSCLC) has propelled a biomarker-directed treatment …
drivers in non-small-cell lung cancer (NSCLC) has propelled a biomarker-directed treatment …
Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective
Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
Targeting apoptosis in cancer therapy
For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
Combining epigenetic drugs with other therapies for solid tumours—past lessons and future promise
Epigenetic dysregulation has long been recognized as a key factor contributing to
tumorigenesis and tumour maintenance that can influence all of the recognized hallmarks of …
tumorigenesis and tumour maintenance that can influence all of the recognized hallmarks of …
The double-edge sword of autophagy in cancer: from tumor suppression to pro-tumor activity
During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …
Understanding and targeting resistance mechanisms in NSCLC
J Rotow, TG Bivona - Nature Reviews Cancer, 2017 - nature.com
The expanding spectrum of both established and candidate oncogenic driver mutations
identified in non-small-cell lung cancer (NSCLC), coupled with the increasing number of …
identified in non-small-cell lung cancer (NSCLC), coupled with the increasing number of …
RNA splicing dysregulation and the hallmarks of cancer
Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …
Cancer-associated splicing alterations arise from both recurrent mutations and altered …
Antitumour immunity regulated by aberrant ERBB family signalling
Aberrant signalling of ERBB family members plays an important role in tumorigenesis and in
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …
Feasibility and utility of a panel testing for 114 cancer‐associated genes in a clinical setting: a hospital‐based study
K Sunami, H Ichikawa, T Kubo, M Kato… - Cancer …, 2019 - Wiley Online Library
Next‐generation sequencing (NGS) of tumor tissue (ie, clinical sequencing) can guide
clinical management by providing information about actionable gene aberrations that have …
clinical management by providing information about actionable gene aberrations that have …
European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia
From the laboratory perspective, effective management of patients with chronic myeloid
leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential …
leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential …