Many essential biological processes including cell regulation and signalling are mediated
through the assembly of protein complexes. Changes to protein-protein interaction (PPI) …

Docking algorithms build multimolecular assemblies based on the subunit
structures.“Unbound” docking, which starts with the free molecules and allows for …

Protein function is often regulated by posttranslational modifications (PTMs), and recent
advances in mass spectrometry have resulted in an exponential increase in PTM …

Protein docking algorithms are assessed by evaluating blind predictions performed during
2007–2009 in Rounds 13–19 of the community‐wide experiment on critical assessment of …

Protein docking algorithms aim to calculate the three‐dimensional (3D) structure of a protein
complex starting from its unbound components. Although ab initio docking algorithms are …

Despite breakthroughs achieved in protein sequence-to-structure and function-to-sequence
predictions, the affinity-to-mutation prediction problem remains unsolved. Such a problem is …

The protein-protein interaction network (PIN) is a useful tool for systematic investigation of
the complex biological activities in the cell. With the increasing interests on the proteome …

Motivation: Accurate binding free energy functions for protein–protein interactions are
imperative for a wide range of purposes. Their construction is predicated upon ascertaining …

Highlights•We review current resources that organize experimental knowledge of the
interaction space.•We present the latest efforts in the prediction of interactions and the …

Recent technological advances enabled high-throughput collection of Small Angle X-ray
Scattering (SAXS) profiles of biological macromolecules. Thus, computational methods for …