The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Although many kinds of therapies are applied in the clinic, drug-resistance is a major and
unavoidable problem. Another disturbing statistic is the limited number of drug targets, which …

Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

Autophagy and mitophagy act in cancer as bimodal processes, whose differential functions
strictly depend on cancer ontogenesis, progression, and type. For instance, they can act to …

Despite the abundant ongoing research efforts, cancer remains one of the most challenging
diseases to treat globally. Due to the heterogenous nature of cancer, one of the major …

Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated
cells, and to interact with its environment to maintain a balance between quiescence …

Altered lipid metabolism is increasingly recognized as a signature of cancer cells. Enabled
by label-free Raman spectromicroscopy, we performed quantitative analysis of lipogenesis …

Breast cancer (BC) is one of the most common causes of cancer in the world and the second
leading cause of cancer deaths among women. Mortality is associated mainly with the …

Cancer stem cells (CSCs) are a subpopulation of tumor cells that possess unique self-
renewal activity and mediate tumor initiation and propagation. The PI3K/Akt/mTOR signaling …