Histone deacetylases (HDACs): evolution, specificity, role in transcriptional complexes, and pharmacological actionability
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …
removing acetyl groups from histones and other protein regulatory factors, with functional …
AMPK: regulation of metabolic dynamics in the context of autophagy
Eukaryotic cells have developed mechanisms that allow them to link growth and proliferation
to the availability of energy and biomolecules. AMPK (adenosine monophosphate-activated …
to the availability of energy and biomolecules. AMPK (adenosine monophosphate-activated …
MOF acetyl transferase regulates transcription and respiration in mitochondria
A functional crosstalk between epigenetic regulators and metabolic control could provide a
mechanism to adapt cellular responses to environmental cues. We report that the well …
mechanism to adapt cellular responses to environmental cues. We report that the well …
The Wnt pathway: An important control mechanism in bone's response to mechanical loading
RB Choi, AG Robling - Bone, 2021 - Elsevier
The conversion of mechanical energy into biochemical changes within living cells is process
known as mechanotransduction. Bone is a quintessential tissue for studying the molecular …
known as mechanotransduction. Bone is a quintessential tissue for studying the molecular …
SIK2 inhibition enhances PARP inhibitor activity synergistically in ovarian and triple-negative breast cancers
Z Lu, W Mao, H Yang… - The Journal of …, 2022 - Am Soc Clin Investig
Poly (ADP-ribose) polymerase inhibitors (PARP inhibitors) have had an increasing role in
the treatment of ovarian and breast cancers. PARP inhibitors are selectively active in cells …
the treatment of ovarian and breast cancers. PARP inhibitors are selectively active in cells …
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal
mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress …
mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress …
HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers
Background Cellular senescence is a permanent state of replicative arrest defined by a
specific pattern of gene expression. The epigenome in senescent cells is sculptured in order …
specific pattern of gene expression. The epigenome in senescent cells is sculptured in order …
[HTML][HTML] HDACs and the epigenetic plasticity of cancer cells: Target the complexity
Cancer cells must adapt to the hostile conditions of the microenvironment in terms of
nutrition, space, and immune system attack. Mutations of DNA are the drivers of the …
nutrition, space, and immune system attack. Mutations of DNA are the drivers of the …
Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease
Histone deacetylases (HDACs) catalyse removal of acetyl groups from lysine residues on
both histone and non‐histone proteins to control numerous cellular processes. Of the 11 …
both histone and non‐histone proteins to control numerous cellular processes. Of the 11 …
HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications
Controlling access to genomic information and maintaining its stability are key aspects of
cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA …
cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA …