E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination
cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2 …

Ubiquitination plays a pivotal role in several cellular processes and is critical for protein
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …

Immune checkpoint blockade (ICB) is a powerful approach for cancer therapy although good
responses are only observed in a fraction of cancer patients. Breast cancers caused by …

Ubiquitination modulates a large repertoire of cellular functions and thus, dysregulation of
the ubiquitin system results in multiple human diseases, including cancer. Ubiquitination …

Panicle size and grain number are important agronomic traits and influence grain yield in
rice (Oryza sativa), but the molecular and genetic mechanisms underlying panicle size and …

Mutations in breast cancer type 1 susceptibility protein (BRCA1) and its heterodimeric
binding partner BARD1 confer a high risk for the development of breast and ovarian …

HECT ubiquitin ligases play essential roles in metazoan development and physiology. The
HECT ligase HUWE1 is central to the cellular stress response by mediating degradation of …

HUWE1 is a universal quality-control E3 ligase that marks diverse client proteins for
proteasomal degradation. Although the giant HECT enzyme is an essential component of …

Although DNA damage repair plays a critical role in cancer chemotherapy, the function of
lncRNAs in this process remains largely unclear. In this study, in silico screening identified …

The histone demethylase JMJD1A, which controls gene expression by epigenetic regulation
of H3K9 methylation marks, functions in diverse activities, including spermatogenesis …