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BCS class IV drugs: Highly notorious candidates for formulation development
BCS class IV drugs (eg, amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel)
exhibit many characteristics that are problematic for effective oral and per oral delivery …
exhibit many characteristics that are problematic for effective oral and per oral delivery …
Nanosizing of drugs: effect on dissolution rate
The solubility, bioavailability and dissolution rate of drugs are important parameters for
achieving in vivo efficiency. The bioavailability of orally administered drugs depends on their …
achieving in vivo efficiency. The bioavailability of orally administered drugs depends on their …
Enhancement of famotidine dissolution rate through liquisolid tablets formulation: in vitro and in vivo evaluation
Although famotidine was reported to be 7.5 and 20 times more potent than ranitidine and
cimetidine, respectively, its oral bioavailability is low and variable; due mainly to its poor …
cimetidine, respectively, its oral bioavailability is low and variable; due mainly to its poor …
Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine)
Y Javadzadeh, B Jafari-Navimipour… - International journal of …, 2007 - Elsevier
Different liquisolid formulations of carbamazepine were accomplished by dissolving the drug
in the non-toxic hydrophilic liquids, and adsorbing the solution onto the surface of silica. In …
in the non-toxic hydrophilic liquids, and adsorbing the solution onto the surface of silica. In …
Effects of liquisolid formulations on dissolution of naproxen
The aim of this study was to investigate the use of liquisolid technique in improving the
dissolution profiles of naproxen in a solid dosage form. This study was designed to evaluate …
dissolution profiles of naproxen in a solid dosage form. This study was designed to evaluate …
Dissolution enhancement of drugs. Part I: technologies and effect of carriers
For complete absorption and good bioavailability of orally administered drug, the drug must
be dissolved in gastric fluids. Dissolution of drug is the rate-controlling step which …
be dissolved in gastric fluids. Dissolution of drug is the rate-controlling step which …
Liquisolid technique as a new approach to sustain propranolol hydrochloride release from tablet matrices
It is suggested here that liquisolid technique has the potential to be optimized for the
reduction of drug dissolution rate and thereby production of sustained release systems. In …
reduction of drug dissolution rate and thereby production of sustained release systems. In …
[PDF][PDF] Solid Dispersion: Methods and Polymers to increase the solubility of poorly soluble drugs
LA Nikghalb, G Singh, G Singh… - Journal of Applied …, 2012 - japsonline.com
The solubility behaviour of drugs remains one of the most exigent aspects in formulation
development. These days, the number of new chemical entities has dramatically increased …
development. These days, the number of new chemical entities has dramatically increased …
Drug release from liquisolid systems: speed it up, slow it down
Introduction: Today, the properties of many new chemical entities have shifted towards
higher molecular weights and this in turn increases the lipophilicity hence decreasing …
higher molecular weights and this in turn increases the lipophilicity hence decreasing …
Suitability of various excipients as carrier and coating materials for liquisolid compacts
CM Hentzschel, A Sakmann… - Drug development and …, 2011 - Taylor & Francis
Context: The liquisolid technology is a promising technique for the release enhancement of
poorly soluble drugs. With this approach, liquids such as solutions or suspensions of poorly …
poorly soluble drugs. With this approach, liquids such as solutions or suspensions of poorly …