Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms

C Szabo, C Ransy, K Módis… - British journal of …, 2014 - Wiley Online Library
Until recently, hydrogen sulfide (H2S) was exclusively viewed a toxic gas and an
environmental hazard, with its toxicity primarily attributed to the inhibition of mitochondrial C …

Mitochondria as a source of reactive oxygen and nitrogen species: from molecular mechanisms to human health

TR Figueira, MH Barros, AA Camargo… - Antioxidants & redox …, 2013 - liebertpub.com
Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …

Riboflavin deficiency—implications for general human health and inborn errors of metabolism

S Mosegaard, G Dipace, P Bross, J Carlsen… - International Journal of …, 2020 - mdpi.com
As an essential vitamin, the role of riboflavin in human diet and health is increasingly being
highlighted. Insufficient dietary intake of riboflavin is often reported in nutritional surveys and …

[HTML][HTML] Metabolism of sulfur-containing amino acids: how the body copes with excess methionine, cysteine, and sulfide

MH Stipanuk - The Journal of nutrition, 2020 - Elsevier
Metabolism of excess methionine (Met) to homocysteine (Hcy) by transmethylation is
facilitated by the expression of methionine adenosyltransferase (MAT) I/III and glycine N …

H2S biosynthesis and catabolism: new insights from molecular studies

P Rose, PK Moore, YZ Zhu - Cellular and Molecular Life Sciences, 2017 - Springer
Hydrogen sulfide (H 2 S) has profound biological effects within living organisms and is now
increasingly being considered alongside other gaseous signalling molecules, such as nitric …

Impact of hydrogen sulfide on mitochondrial and bacterial bioenergetics

VB Borisov, E Forte - International Journal of Molecular Sciences, 2021 - mdpi.com
This review focuses on the effects of hydrogen sulfide (H2S) on the unique bioenergetic
molecular machines in mitochondria and bacteria—the protein complexes of electron …

Hydrogen sulfide and the liver

S Mani, W Cao, L Wu, R Wang - Nitric Oxide, 2014 - Elsevier
Hydrogen sulfide (H 2 S) is a gasotransmitter that regulates numerous physiological and
pathophysiological processes in our body. Enzymatic production of H 2 S is catalyzed by …

Impaired muscle mitochondrial biogenesis and myogenesis in spinal muscular atrophy

M Ripolone, D Ronchi, R Violano, D Vallejo… - JAMA …, 2015 - jamanetwork.com
Importance The important depletion of mitochondrial DNA (mtDNA) and the general
depression of mitochondrial respiratory chain complex levels (including complex II) have …

Hydrogen sulfide oxidation by myoglobin

T Bostelaar, V Vitvitsky, J Kumutima… - Journal of the …, 2016 - ACS Publications
Enzymes in the sulfur network generate the signaling molecule, hydrogen sulfide (H2S),
from the amino acids cysteine and homocysteine. Since it is toxic at elevated concentrations …